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Molecules 2012, 17(5), 4915-4923; doi:10.3390/molecules17054915
Article

Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex

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Received: 14 April 2012; in revised form: 16 April 2012 / Accepted: 16 April 2012 / Published: 30 April 2012
(This article belongs to the Section Metabolites)
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Abstract: Two new monoterpene diglycosides, suffruyabiosides A (1) and B (2), and seven known compounds 39 were isolated from Moutan Cortex (root cortex of Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A (1) and B (2) are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 > mudanpioside E (6) > oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution. The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent.
Keywords: monoterpene diglycoside; suffruyabiosides A and B; human lung adenocarcinoma epitherial A549 cells; radical scavenging effect monoterpene diglycoside; suffruyabiosides A and B; human lung adenocarcinoma epitherial A549 cells; radical scavenging effect
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Furuya, R.; Hu, H.; Zhang, Z.; Shigemori, H. Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex. Molecules 2012, 17, 4915-4923.

AMA Style

Furuya R, Hu H, Zhang Z, Shigemori H. Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex. Molecules. 2012; 17(5):4915-4923.

Chicago/Turabian Style

Furuya, Rie; Hu, Honghai; Zhang, Zhenya; Shigemori, Hideyuki. 2012. "Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex." Molecules 17, no. 5: 4915-4923.



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