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Molecules 2012, 17(4), 4313-4325; doi:10.3390/molecules17044313
Communication

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

,  and *
Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 30 March 2012 / Accepted: 31 March 2012 / Published: 10 April 2012
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Abstract

A three step synthesis of various thiobarbiturate derivatives 1724 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 18 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.
Keywords: manganese(III) acetate; barbiturates; radical manganese(III) acetate; barbiturates; radical
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Bouhlel, A.; Curti, C.; Vanelle, P. New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate. Molecules 2012, 17, 4313-4325.

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