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Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans
Molecules 2012, 17(4), 4313-4325; doi:10.3390/molecules17044313

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

,  and *
Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 15 March 2012 / Revised: 30 March 2012 / Accepted: 31 March 2012 / Published: 10 April 2012
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A three step synthesis of various thiobarbiturate derivatives 1724 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 18 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.
Keywords: manganese(III) acetate; barbiturates; radical manganese(III) acetate; barbiturates; radical
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bouhlel, A.; Curti, C.; Vanelle, P. New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate. Molecules 2012, 17, 4313-4325.

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