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Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins
Chemistry Department, Amazonas Federal University, Av. Gal. Rodrigo Octávio, 6.200, Japiim, Manaus-AM, 69080-900, Brazil
Graduate Program on Pharmaceutical Sciences, Paraíba State University, Rua Baraúnas, 351, Bairro Universitário, Campina Grande-PB, 58429-500, Brazil
* Author to whom correspondence should be addressed.
Received: 12 December 2011; in revised form: 18 March 2012 / Accepted: 22 March 2012 / Published: 30 March 2012
(This article belongs to the Special Issue Terpenoids
Abstract: Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
Keywords: copaiba oil; oleoresin; sesquiterpenes; diterpenes; pharmacological activities
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Cite This Article
MDPI and ACS Style
Leandro, L.M.; de Sousa Vargas, F.; Barbosa, P.C.S.; Neves, J.K.O.; da Silva, J.A.; da Veiga-Junior, V.F. Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins. Molecules 2012, 17, 3866-3889.
Leandro LM, de Sousa Vargas F, Barbosa PCS, Neves JKO, da Silva JA, da Veiga-Junior VF. Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins. Molecules. 2012; 17(4):3866-3889.
Leandro, Lidiam Maia; de Sousa Vargas, Fabiano; Barbosa, Paula Cristina Souza; Neves, Jamilly Kelly Oliveira; da Silva, José Alexsandro; da Veiga-Junior, Valdir Florêncio. 2012. "Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins." Molecules 17, no. 4: 3866-3889.