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Molecules 2012, 17(4), 3866-3889; doi:10.3390/molecules17043866

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

1, 1, 1, 2, 2 and 1,*
1 Chemistry Department, Amazonas Federal University, Av. Gal. Rodrigo Octávio, 6.200, Japiim, Manaus-AM, 69080-900, Brazil 2 Graduate Program on Pharmaceutical Sciences, Paraíba State University, Rua Baraúnas, 351, Bairro Universitário, Campina Grande-PB, 58429-500, Brazil
* Author to whom correspondence should be addressed.
Received: 12 December 2011 / Revised: 18 March 2012 / Accepted: 22 March 2012 / Published: 30 March 2012
(This article belongs to the Special Issue Terpenoids)
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Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
Keywords: copaiba oil; oleoresin; sesquiterpenes; diterpenes; pharmacological activities copaiba oil; oleoresin; sesquiterpenes; diterpenes; pharmacological activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Leandro, L.M.; de Sousa Vargas, F.; Barbosa, P.C.S.; Neves, J.K.O.; da Silva, J.A.; da Veiga-Junior, V.F. Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins. Molecules 2012, 17, 3866-3889.

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