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Molecules 2012, 17(2), 1992-1999; doi:10.3390/molecules17021992
Article

Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives

,
 and
*
Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
* Author to whom correspondence should be addressed.
Received: 14 November 2011 / Revised: 19 January 2012 / Accepted: 6 February 2012 / Published: 17 February 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.
Keywords: bis(oxazoline); asymmetric catalysis; allylic alkylation bis(oxazoline); asymmetric catalysis; allylic alkylation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, L.; Ma, H.; Fu, B. Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives. Molecules 2012, 17, 1992-1999.

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