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Molecules 2012, 17(12), 14841-14845; doi:10.3390/molecules171214841

A General Synthesis of Bis-indolylpiperazine-2,5-diones

1 Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA 2 Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA
* Author to whom correspondence should be addressed.
Received: 15 November 2012 / Revised: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
(This article belongs to the Section Organic Synthesis)
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The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
Keywords: indole; bromination; dragmacidin derivatives indole; bromination; dragmacidin derivatives
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.

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