A General Synthesis of Bis-indolylpiperazine-2,5-diones

doi:10.3390/molecules171214841

This article is

freely available
re-usable

Molecules 2012, 17(12), 14841-14845; doi:10.3390/molecules171214841

Article

A General Synthesis of Bis-indolylpiperazine-2,5-diones

Stephen Crooke¹ and Christine Whitlock^2,*

¹ Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA ² Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA

* Author to whom correspondence should be addressed.

Received: 15 November 2012; in revised form: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012

(This article belongs to the Section Organic Synthesis)

Download PDF Full-Text [177 KB, uploaded 13 December 2012 10:59 CET]

Abstract: The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by ¹H-NMR.

Keywords: indole; bromination; dragmacidin derivatives

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.

AMA Style

Crooke S, Whitlock C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules. 2012; 17(12):14841-14845.

Chicago/Turabian Style

Crooke, Stephen; Whitlock, Christine. 2012. "A General Synthesis of Bis-indolylpiperazine-2,5-diones." Molecules 17, no. 12: 14841-14845.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert