Molecules 2012, 17(12), 14841-14845; doi:10.3390/molecules171214841

A General Synthesis of Bis-indolylpiperazine-2,5-diones

1email and 2,* email
Received: 15 November 2012; in revised form: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
Keywords: indole; bromination; dragmacidin derivatives
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MDPI and ACS Style

Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.

AMA Style

Crooke S, Whitlock C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules. 2012; 17(12):14841-14845.

Chicago/Turabian Style

Crooke, Stephen; Whitlock, Christine. 2012. "A General Synthesis of Bis-indolylpiperazine-2,5-diones." Molecules 17, no. 12: 14841-14845.

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