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A General Synthesis of Bis-indolylpiperazine-2,5-diones
Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA
Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA
* Author to whom correspondence should be addressed.
Received: 15 November 2012; in revised form: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
Abstract: The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
Keywords: indole; bromination; dragmacidin derivatives
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Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.
Crooke S, Whitlock C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules. 2012; 17(12):14841-14845.
Crooke, Stephen; Whitlock, Christine. 2012. "A General Synthesis of Bis-indolylpiperazine-2,5-diones." Molecules 17, no. 12: 14841-14845.