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Molecules 2012, 17(12), 14841-14845; doi:10.3390/molecules171214841

A General Synthesis of Bis-indolylpiperazine-2,5-diones

1 Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA 2 Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA
* Author to whom correspondence should be addressed.
Received: 15 November 2012 / Revised: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
(This article belongs to the Section Organic Synthesis)
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The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
Keywords: indole; bromination; dragmacidin derivatives indole; bromination; dragmacidin derivatives
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.

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