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Molecules 2012, 17(12), 14810-14820; doi:10.3390/molecules171214810

Microbial Transformations of 7-Methoxyflavanone

Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, Wrocław 50-375, Poland
Author to whom correspondence should be addressed.
Received: 2 November 2012 / Revised: 16 November 2012 / Accepted: 30 November 2012 / Published: 11 December 2012
(This article belongs to the Section Natural Products)
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Microbial transformations of racemic 7-methoxyflavanone using strains of the genus Aspergillus (A. niger KB, A. ochraceus 456) and the strain Penicillium chermesinum 113 were described. The strain A. niger KB catalysed carbonyl group reduction, leading to (±)-2,4-cis-7-methoxyflavan-4-ol. Biotransformation with the help of A. ochraceus 456 gave two products: (+)-2,4-trans-7-methoxyflavan-4-ol and 4'-hydroxy-7-methoxyflavone. Transformation by means of P. chermesinum 113 resulted in a dihydrochalcone product, 4,2'-dihydroxy-4'-methoxydihydrochalcone. DPPH scavenging activity test proved that all the biotransformations products have higher antioxidant activity that the substrate.
Keywords: biotransformation; 7-methoxyflavanone; Aspergillus niger; Aspergillus ochraceus; Penicillium chermesinum biotransformation; 7-methoxyflavanone; Aspergillus niger; Aspergillus ochraceus; Penicillium chermesinum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kostrzewa-Susłow, E.; Janeczko, T. Microbial Transformations of 7-Methoxyflavanone. Molecules 2012, 17, 14810-14820.

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