Next Article in Journal
Efficient Preparation of α-Ketoacetals
Previous Article in Journal
Influence of Nonpolar Substances on the Extraction Efficiency of Six Alkaloids in Zoagumhwan Investigated by Ultra Performance Liquid Chromatography and Photodiode Array Detection
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(12), 13856-13863; doi:10.3390/molecules171213856

An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

1,2,†,* , 2,†, 2 and 3
Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China
Department of Chemistry, Xuzhou Medical College, Xuzhou 221004, China
School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 5 November 2012 / Revised: 17 November 2012 / Accepted: 20 November 2012 / Published: 22 November 2012
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [222 KB, uploaded 18 June 2014]   |  


A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
Keywords: pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhu, S.; Wang, J.; Xu, Z.; Li, J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules 2012, 17, 13856-13863.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top