Molecules 2012, 17(12), 13856-13863; doi:10.3390/molecules171213856
Article

An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

1,2,†,* email, 2,†, 2 and 3
1 Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China 2 Department of Chemistry, Xuzhou Medical College, Xuzhou 221004, China 3 School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 November 2012; in revised form: 17 November 2012 / Accepted: 20 November 2012 / Published: 22 November 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
Keywords: pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline

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MDPI and ACS Style

Zhu, S.; Wang, J.; Xu, Z.; Li, J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules 2012, 17, 13856-13863.

AMA Style

Zhu S, Wang J, Xu Z, Li J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules. 2012; 17(12):13856-13863.

Chicago/Turabian Style

Zhu, Songlei; Wang, Jing; Xu, Zhou; Li, Jie. 2012. "An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline." Molecules 17, no. 12: 13856-13863.

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