Molecules 2012, 17(12), 13856-13863; doi:10.3390/molecules171213856
Article

An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

1,2,†,* email, 2,†, 2 and 3
Received: 5 November 2012; in revised form: 17 November 2012 / Accepted: 20 November 2012 / Published: 22 November 2012
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
Keywords: pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline
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MDPI and ACS Style

Zhu, S.; Wang, J.; Xu, Z.; Li, J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules 2012, 17, 13856-13863.

AMA Style

Zhu S, Wang J, Xu Z, Li J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules. 2012; 17(12):13856-13863.

Chicago/Turabian Style

Zhu, Songlei; Wang, Jing; Xu, Zhou; Li, Jie. 2012. "An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline." Molecules 17, no. 12: 13856-13863.

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