Next Article in Journal
Efficient Preparation of α-Ketoacetals
Previous Article in Journal
Influence of Nonpolar Substances on the Extraction Efficiency of Six Alkaloids in Zoagumhwan Investigated by Ultra Performance Liquid Chromatography and Photodiode Array Detection
Molecules 2012, 17(12), 13856-13863; doi:10.3390/molecules171213856
Article

An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

1,2,†,* , 2,†, 2 and 3
Received: 5 November 2012 / Revised: 17 November 2012 / Accepted: 20 November 2012 / Published: 22 November 2012
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [222 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
Keywords: pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Zhu, S.; Wang, J.; Xu, Z.; Li, J. An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline. Molecules 2012, 17, 13856-13863.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert