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Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities
Department of Neurosurgery, Institue of Neurology, General Hospital of Shenyang Military Area Command, Shenyang Northern Hospital, #83 Wenhua Road, Shenhe District, Shenyang 110018, China
* Author to whom correspondence should be addressed.
Received: 12 October 2012; in revised form: 8 November 2012 / Accepted: 12 November 2012 / Published: 16 November 2012
Abstract: The 80% ethanol extract of Alstonia yunnanensis afforded five new monoterpenoid indole alkaloids: 11-hydroxy-6,7-epoxy-8-oxo-vincadifformine (1), 14-chloro-15-hydroxy- vincadifformine (2), perakine N4-oxide (3), raucaffrinoline N4-oxide (4), and vinorine N1,N4-dioxide (5), together with three known compounds: 11-methoxy-6,7-epoxy-8-oxo- vincadifformine (6), vinorine N4-oxide (7) and vinorine (8). The structures of the isolated compounds were established based on 1D and 2D (1H-1H-COSY, HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic potential against seven tumor cell lines and anti-inflammatory activities. Compounds 3, 4 and 7 exhibited weak cytotoxicity against the tested cell lines and selective inhibition of Cox-2 (>85%).
Keywords: Alstonia yunnanensis; Apocynaceae; monoterpenoid indole alkaloids; cytotoxicity; anti-inflammatory activities
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MDPI and ACS Style
Cao, P.; Liang, Y.; Gao, X.; Li, X.-M.; Song, Z.-Q.; Liang, G. Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities. Molecules 2012, 17, 13631-13641.
Cao P, Liang Y, Gao X, Li X-M, Song Z-Q, Liang G. Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities. Molecules. 2012; 17(11):13631-13641.
Cao, Peng; Liang, Yong; Gao, Xu; Li, Xiao-Ming; Song, Zhen-Quan; Liang, Guobiao. 2012. "Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities." Molecules 17, no. 11: 13631-13641.