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Molecules 2012, 17(11), 13631-13641; doi:10.3390/molecules171113631
Article

Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities

, , , ,  and *
Department of Neurosurgery, Institue of Neurology, General Hospital of Shenyang Military Area Command, Shenyang Northern Hospital, #83 Wenhua Road, Shenhe District, Shenyang 110018, China
* Author to whom correspondence should be addressed.
Received: 12 October 2012 / Revised: 8 November 2012 / Accepted: 12 November 2012 / Published: 16 November 2012
(This article belongs to the Section Metabolites)
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Abstract

The 80% ethanol extract of Alstonia yunnanensis afforded five new monoterpenoid indole alkaloids: 11-hydroxy-6,7-epoxy-8-oxo-vincadifformine (1), 14-chloro-15-hydroxy- vincadifformine (2), perakine N4-oxide (3), raucaffrinoline N4-oxide (4), and vinorine N1,N4-dioxide (5), together with three known compounds: 11-methoxy-6,7-epoxy-8-oxo- vincadifformine (6), vinorine N4-oxide (7) and vinorine (8). The structures of the isolated compounds were established based on 1D and 2D (1H-1H-COSY, HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic potential against seven tumor cell lines and anti-inflammatory activities. Compounds 3, 4 and 7 exhibited weak cytotoxicity against the tested cell lines and selective inhibition of Cox-2 (>85%).
Keywords: Alstonia yunnanensis; Apocynaceae; monoterpenoid indole alkaloids; cytotoxicity; anti-inflammatory activities Alstonia yunnanensis; Apocynaceae; monoterpenoid indole alkaloids; cytotoxicity; anti-inflammatory activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cao, P.; Liang, Y.; Gao, X.; Li, X.-M.; Song, Z.-Q.; Liang, G. Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities. Molecules 2012, 17, 13631-13641.

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