Molecules 2012, 17(11), 12758-12770; doi:10.3390/molecules171112758
Article

Formation and Inhibition of Nε-(Carboxymethyl)lysine in Saccharide-Lysine Model Systems during Microwave Heating

Received: 5 September 2012; in revised form: 21 September 2012 / Accepted: 10 October 2012 / Published: 31 October 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nε-(carboxymethyl) lysine (CML) is the most abundant advanced glycation end product (AGE), and frequently selected as an AGEs marker in laboratory studies. In this paper, the formation and inhibition of Nε-(carboxymethyl)lysine in saccharide-lysine model systems during microwave heating have been studied. The microwave heating treatment significantly promoted the formation of CML during Maillard reactions, which was related to the reaction temperature, time and type of saccharide. The order of CML formation for different saccharides was lactose > glucose > sucrose. Then, the inhibition effect on CML by five inhibitors was further examined. According to the results, ascorbic acid and tocopherol did not affect inhibition of CML, in contrast, thiamin, rutin and quercetin inhibited CML formation, and the inhibitory effects were concentration dependent.
Keywords: Nε-(carboxymethyl)lysine; microwave heating; formation; inhibition
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MDPI and ACS Style

Li, L.; Han, L.; Fu, Q.; Li, Y.; Liang, Z.; Su, J.; Li, B. Formation and Inhibition of Nε-(Carboxymethyl)lysine in Saccharide-Lysine Model Systems during Microwave Heating. Molecules 2012, 17, 12758-12770.

AMA Style

Li L, Han L, Fu Q, Li Y, Liang Z, Su J, Li B. Formation and Inhibition of Nε-(Carboxymethyl)lysine in Saccharide-Lysine Model Systems during Microwave Heating. Molecules. 2012; 17(11):12758-12770.

Chicago/Turabian Style

Li, Lin; Han, Lipeng; Fu, Quanyi; Li, Yuting; Liang, Zhili; Su, Jianyu; Li, Bing. 2012. "Formation and Inhibition of Nε-(Carboxymethyl)lysine in Saccharide-Lysine Model Systems during Microwave Heating." Molecules 17, no. 11: 12758-12770.

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