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Molecules 2012, 17(11), 12704-12717; doi:10.3390/molecules171112704
Article

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

1,†, 2,†, 3, 1, 1, 4, 4, 4, 1,*  and 4,*
Received: 4 September 2012; in revised form: 16 October 2012 / Accepted: 18 October 2012 / Published: 26 October 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
Keywords: dispirooxindole; three-component reaction; 1,3-dipolar cycloaddition; azomethine ylide dispirooxindole; three-component reaction; 1,3-dipolar cycloaddition; azomethine ylide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, Z.; Zhao, Q.; Chen, G.; Wang, H.; Lin, W.; Xu, L.; Liu, H.; Wang, J.; Shi, D.; Wang, Y. An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions. Molecules 2012, 17, 12704-12717.

AMA Style

Huang Z, Zhao Q, Chen G, Wang H, Lin W, Xu L, Liu H, Wang J, Shi D, Wang Y. An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions. Molecules. 2012; 17(11):12704-12717.

Chicago/Turabian Style

Huang, Zhibin; Zhao, Qian; Chen, Gang; Wang, Huiyuan; Lin, Wei; Xu, Lexing; Liu, Hongtao; Wang, Juxian; Shi, Daqing; Wang, Yucheng. 2012. "An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions." Molecules 17, no. 11: 12704-12717.


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