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Antimicrobial Peptides for Therapeutic Applications: A Review
College of Pharmacy, Ajou University, Suwon 443-749, Korea
Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, Korea
Center for Structural Biology and Departments of Biochemistry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Faculty of Biology, National University of Mongolia, Ulaanbaatar Box 377, Mongolia
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
* Author to whom correspondence should be addressed.
Received: 12 September 2012; in revised form: 8 October 2012 / Accepted: 17 October 2012 / Published: 18 October 2012
Abstract: Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to conventional antibiotics. Although AMPs possess considerable benefits as new generation antibiotics, their clinical and commercial development still have some limitations, such as potential toxicity, susceptibility to proteases, and high cost of peptide production. In order to overcome those obstacles, extensive efforts have been carried out. For instance, unusual amino acids or peptido-mimetics are introduced to avoid the proteolytic degradation and the design of short peptides retaining antimicrobial activities is proposed as a solution for the cost issue. In this review, we focus on small peptides, especially those with less than twelve amino acids, and provide an overview of the relationships between their three-dimensional structures and antimicrobial activities. The efforts to develop highly active AMPs with shorter sequences are also described.
Keywords: antimicrobial peptides (AMPs); antibiotics; structure-activity relationship (SAR)
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Seo, M.-D.; Won, H.-S.; Kim, J.-H.; Mishig-Ochir, T.; Lee, B.-J. Antimicrobial Peptides for Therapeutic Applications: A Review. Molecules 2012, 17, 12276-12286.
Seo M-D, Won H-S, Kim J-H, Mishig-Ochir T, Lee B-J. Antimicrobial Peptides for Therapeutic Applications: A Review. Molecules. 2012; 17(10):12276-12286.
Seo, Min-Duk; Won, Hyung-Sik; Kim, Ji-Hun; Mishig-Ochir, Tsogbadrakh; Lee, Bong-Jin. 2012. "Antimicrobial Peptides for Therapeutic Applications: A Review." Molecules 17, no. 10: 12276-12286.