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Molecules 2012, 17(10), 11877-11896; doi:10.3390/molecules171011877
Article

Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation

1,2,* , 2 and 2,3
Received: 23 July 2012; in revised form: 5 September 2012 / Accepted: 18 September 2012 / Published: 9 October 2012
(This article belongs to the Special Issue Advances in Carbohydrate Chemistry)
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Abstract: A series of novel glycol-clusters containing sulfonated N-acetyl-D-glucosamine (GlcNAc) have been synthesized using click chemistry. Three dendrimers with aromatic dendrons were synthesized using chlorination, azidation and click chemistries. The resulting dendrimers were modified with azide-terminated sulfonated GlcNAc using click chemistry. The sulfonated dendrimers showed affinity for proteins, including the lectin wheat germ agglutinin and amyloid beta peptide (1-42). The dendrimers of G1 and G2 in particular showed the largest affinity for the proteins. The addition of the sulfonated GlcNAc dendrimers of G1 and G2 exhibited an inhibition effect on the aggregation of the amyloid beta peptide, reduced the b-sheet conformation, and led to a reduction in the level of nanofiber formation.
Keywords: glycopolymer; dendrimer; click chemistry; amyloidosis glycopolymer; dendrimer; click chemistry; amyloidosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Miura, Y.; Onogi, S.; Fukuda, T. Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation. Molecules 2012, 17, 11877-11896.

AMA Style

Miura Y, Onogi S, Fukuda T. Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation. Molecules. 2012; 17(10):11877-11896.

Chicago/Turabian Style

Miura, Yoshiko; Onogi, Shunsuke; Fukuda, Tomohiro. 2012. "Syntheses of Sulfo-Glycodendrimers Using Click Chemistry and Their Biological Evaluation." Molecules 17, no. 10: 11877-11896.



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