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Molecules 2012, 17(10), 11456-11468; doi:10.3390/molecules171011456
Article

Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane

1, 2, 2, 2, 1, 1 and 2,*
Received: 2 August 2012; in revised form: 24 September 2012 / Accepted: 25 September 2012 / Published: 27 September 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 µg/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations.
Keywords: thienyl derivatives; T98G gliomas; HEK cells thienyl derivatives; T98G gliomas; HEK cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kaushik, N.K.; Kim, H.S.; Chae, Y.J.; Lee, Y.N.; Kwon, G.-C.; Choi, E.H.; Kim, I.T. Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane. Molecules 2012, 17, 11456-11468.

AMA Style

Kaushik NK, Kim HS, Chae YJ, Lee YN, Kwon G-C, Choi EH, Kim IT. Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane. Molecules. 2012; 17(10):11456-11468.

Chicago/Turabian Style

Kaushik, Nagendra Kumar; Kim, Hong Seon; Chae, Young June; Lee, Young Nam; Kwon, Gi-Chung; Choi, Eun Ha; Kim, In Tae. 2012. "Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane." Molecules 17, no. 10: 11456-11468.


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