Molecules 2012, 17(1), 861-872; doi:10.3390/molecules17010861
Article

Phytochemical Study and Anti-inflammatory, Antidiabetic and Free Radical Scavenger Evaluations of Krameria pauciflora Methanol Extract

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Received: 16 December 2011; in revised form: 13 January 2012 / Accepted: 13 January 2012 / Published: 17 January 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete methanol and dichloromethane extracts showed anti-inflammatory effects at 3 mg/kg. An anti-inflammatory effect similar to indomethacin (10 mg/kg) was observed when the methanol and dichloromethane extracts, which contain a cycloartane-type triterpene and an sterol, were administered orally at several doses (3, 10, 30 and 100 mg/kg), whereas no anti-inflammatory effect was observed at any dose for the ethyl acetate extract, which contains catechin-type flavonoids. The antidiabetic effect of each extract was also determined. An antihyperglycaemic effect was observed in diabetic rats, but no effect in normoglycaemic animals was observed when the methanol extract was administrated at 30 mg/kg. All of the extracts exhibited radical scavenger activity. Additionally, constituents from all of the extracts were identified by NMR. This article supports the use of K. pauciflora as an anti-inflammatory because it exhibits a similar effect to indomethacin. However, its antidiabetic effect is not completely clear, although it could be useful for preventing diabetic complications.
Keywords: Krameria pauciflora; anti-inflammatory; antidiabetic; cycloartanes; catechins
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MDPI and ACS Style

Ramírez-Cisneros, M.Á.; Rios, M.Y.; Déciga-Campos, M.; Aguilar-Guadarrama, A.B. Phytochemical Study and Anti-inflammatory, Antidiabetic and Free Radical Scavenger Evaluations of Krameria pauciflora Methanol Extract. Molecules 2012, 17, 861-872.

AMA Style

Ramírez-Cisneros MÁ, Rios MY, Déciga-Campos M, Aguilar-Guadarrama AB. Phytochemical Study and Anti-inflammatory, Antidiabetic and Free Radical Scavenger Evaluations of Krameria pauciflora Methanol Extract. Molecules. 2012; 17(1):861-872.

Chicago/Turabian Style

Ramírez-Cisneros, M. Ángeles; Rios, María Yolanda; Déciga-Campos, Myrna; Aguilar-Guadarrama, A. Berenice. 2012. "Phytochemical Study and Anti-inflammatory, Antidiabetic and Free Radical Scavenger Evaluations of Krameria pauciflora Methanol Extract." Molecules 17, no. 1: 861-872.


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