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Molecules 2012, 17(1), 227-239; doi:10.3390/molecules17010227

Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

1, 1, 2, 3, 4, 5 and 1,†,*
Received: 15 November 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Heterocycles)
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A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 810 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 57, mediated by polyphosphoric acid (PPA). The amidrazones themselves were synthesized via direct interaction of the appropriate hydrazonoyl chlorides 4ad with the corresponding N-substituted piperazine in the presence of triethylamine. The structures of the new prepared compounds were confirmed by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor, antibacterial, and antifungal activity of the newly synthesized compounds was evaluated.
Keywords: hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Awad, E.D.; El-Abadelah, M.M.; Matar, S.; Zihlif, M.A.; Naffa, R.G.; Al-Momani, E.Q.; Mubarak, M.S. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines. Molecules 2012, 17, 227-239.

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