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Molecules 2012, 17(1), 227-239; doi:10.3390/molecules17010227
Article

Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

1, 1, 2, 3, 4, 5 and 1,†,*
1 Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan 2 Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan 3 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 4 Laboratory of Molecular Biology Research, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 5 Clinic of Nuclear Medicine, Ulm University, Ulm 89081, Germany Present address: Al-Ghad International Colleges of Health Sciences, P.O. Box 2174, Riyadh 11451, Saudi Arabia.
* Author to whom correspondence should be addressed.
Received: 15 November 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 810 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 57, mediated by polyphosphoric acid (PPA). The amidrazones themselves were synthesized via direct interaction of the appropriate hydrazonoyl chlorides 4ad with the corresponding N-substituted piperazine in the presence of triethylamine. The structures of the new prepared compounds were confirmed by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor, antibacterial, and antifungal activity of the newly synthesized compounds was evaluated.
Keywords: hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Awad, E.D.; El-Abadelah, M.M.; Matar, S.; Zihlif, M.A.; Naffa, R.G.; Al-Momani, E.Q.; Mubarak, M.S. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines. Molecules 2012, 17, 227-239.

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