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Molecules 2012, 17(1), 227-239; doi:10.3390/molecules17010227

Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

1
Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan
2
Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan
3
Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan
4
Laboratory of Molecular Biology Research, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan
5
Clinic of Nuclear Medicine, Ulm University, Ulm 89081, Germany
Present address: Al-Ghad International Colleges of Health Sciences, P.O. Box 2174, Riyadh 11451, Saudi Arabia.
*
Author to whom correspondence should be addressed.
Received: 15 November 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 810 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 57, mediated by polyphosphoric acid (PPA). The amidrazones themselves were synthesized via direct interaction of the appropriate hydrazonoyl chlorides 4ad with the corresponding N-substituted piperazine in the presence of triethylamine. The structures of the new prepared compounds were confirmed by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor, antibacterial, and antifungal activity of the newly synthesized compounds was evaluated.
Keywords: hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Awad, E.D.; El-Abadelah, M.M.; Matar, S.; Zihlif, M.A.; Naffa, R.G.; Al-Momani, E.Q.; Mubarak, M.S. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines. Molecules 2012, 17, 227-239.

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