Abstract: A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 8–10 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 5–7, mediated by polyphosphoric acid (PPA). The amidrazones themselves were synthesized via direct interaction of the appropriate hydrazonoyl chlorides 4a–d with the corresponding N-substituted piperazine in the presence of triethylamine. The structures of the new prepared compounds were confirmed by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor, antibacterial, and antifungal activity of the newly synthesized compounds was evaluated.
Keywords: hydrazonoyl chlorides; 3-(piperazin-1-yl)cinnolines; antitumor and antifungal activity
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Awad, E.D.; El-Abadelah, M.M.; Matar, S.; Zihlif, M.A.; Naffa, R.G.; Al-Momani, E.Q.; Mubarak, M.S. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines. Molecules 2012, 17, 227-239.
Awad ED, El-Abadelah MM, Matar S, Zihlif MA, Naffa RG, Al-Momani EQ, Mubarak MS. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines. Molecules. 2012; 17(1):227-239.
Awad, Eman D.; El-Abadelah, Mustafa M.; Matar, Suzan; Zihlif, Malek A.; Naffa, Randa G.; Al-Momani, Ehab Q.; Mubarak, Mohammad S. 2012. "Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines." Molecules 17, no. 1: 227-239.