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Molecules 2011, 16(9), 7288-7301; doi:10.3390/molecules16097288

Development of a Process for Separation of Mogroside V from Siraitia grosvenorii by Macroporous Resins

1
Modern Engineering Center for Traditional Chinese Medicine, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
2
College of Computer Science and Control, Guilin University of Electronic Technology, Guilin 541004, China
3
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
Received: 1 July 2011 / Revised: 15 August 2011 / Accepted: 16 August 2011 / Published: 25 August 2011
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Abstract

A separation method was developed for the preparative separation and enrichment of the non-caloric sweetener mogroside V from Siraitia grosvenorii. The adsorption properties of six macroporous resins were evaluated. Results showed that HZ 806 resin offered the best adsorption and desorption capacities. Based on the adsorption experiments on HZ 806, the adsorption data were found to fit the Freundlich model well. The pseudo-second-order kinetic model showed the highest correlation with the experimental results. Separation was performed with deionized water and 40% aqueous ethanol solution as mobile phases. In a typical run, 100 g of herb was processed and 3.38 g of mogroside V with a purity of 10.7% was harvested. This separation method provided a 15.1-fold increase in the purification factor from 0.5% to 10.7%. The present study showed that HZ 806 resins were effective for the separation and enrichment of mogroside V from S. grosvenorii.
Keywords: mogrosides V; Siraitia grosvenorii; macroporous resins; separation; enrichment mogrosides V; Siraitia grosvenorii; macroporous resins; separation; enrichment
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, M.; Yang, H.; Zhang, H.; Wang, Y.; Hu, P. Development of a Process for Separation of Mogroside V from Siraitia grosvenorii by Macroporous Resins. Molecules 2011, 16, 7288-7301.

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