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Molecules 2011, 16(8), 6985-6991; doi:10.3390/molecules16086985

Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China
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Received: 11 July 2011 / Revised: 6 August 2011 / Accepted: 9 August 2011 / Published: 16 August 2011
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Abstract

New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.
Keywords: riminophenazine; N-arylation; palladium catalyst riminophenazine; N-arylation; palladium catalyst
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, G.; Zhang, H.; Wang, X.; Li, C.; Huang, H.; Yin, D. Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position. Molecules 2011, 16, 6985-6991.

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