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Molecules 2011, 16(8), 6985-6991; doi:10.3390/molecules16086985

Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

, , , ,  and *
Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 11 July 2011 / Revised: 6 August 2011 / Accepted: 9 August 2011 / Published: 16 August 2011
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New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.
Keywords: riminophenazine; N-arylation; palladium catalyst riminophenazine; N-arylation; palladium catalyst
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, G.; Zhang, H.; Wang, X.; Li, C.; Huang, H.; Yin, D. Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position. Molecules 2011, 16, 6985-6991.

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