Molecules 2011, 16(8), 6985-6991; doi:10.3390/molecules16086985
Article

Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 11 July 2011; in revised form: 6 August 2011 / Accepted: 9 August 2011 / Published: 16 August 2011
PDF Full-text Download PDF Full-Text [477 KB, uploaded 16 August 2011 10:15 CEST]
Abstract: New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd2(dba)3/DPPF/Cs2CO3/toluene combination.
Keywords: riminophenazine; N-arylation; palladium catalyst

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Zhang, G.; Zhang, H.; Wang, X.; Li, C.; Huang, H.; Yin, D. Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position. Molecules 2011, 16, 6985-6991.

AMA Style

Zhang G, Zhang H, Wang X, Li C, Huang H, Yin D. Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position. Molecules. 2011; 16(8):6985-6991.

Chicago/Turabian Style

Zhang, Gang; Zhang, Hao; Wang, Xiaojian; Li, Chun; Huang, Haihong; Yin, Dali. 2011. "Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position." Molecules 16, no. 8: 6985-6991.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert