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Molecules 2011, 16(8), 6858-6870; doi:10.3390/molecules16086858
Article

Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors

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Received: 18 July 2011; in revised form: 4 August 2011 / Accepted: 8 August 2011 / Published: 11 August 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
Download PDF [511 KB, uploaded 18 June 2014]
Abstract: Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development of some three-dimensional pharmacophore models which have led to the identification of a large series of potent HIV-1 integrase strand-transfer inhibitors (INSTIs) bearing an indole core. To gain a better understanding of the structure-activity relationships (SARs), herein we report the design and microwave-assisted synthesis of a novel series of 1-H-benzylindole derivatives.
Keywords: AIDS; integrase inhibitors; small molecules; MAOS AIDS; integrase inhibitors; small molecules; MAOS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ferro, S.; Grazia, S.D.; Luca, L.D.; Gitto, R.; Faliti, C.E.; Debyzer, Z.; Chimirri, A. Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors. Molecules 2011, 16, 6858-6870.

AMA Style

Ferro S, Grazia SD, Luca LD, Gitto R, Faliti CE, Debyzer Z, Chimirri A. Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors. Molecules. 2011; 16(8):6858-6870.

Chicago/Turabian Style

Ferro, Stefania; Grazia, Sara De; Luca, Laura De; Gitto, Rosaria; Faliti, Caterina Elisa; Debyzer, Zeger; Chimirri, Alba. 2011. "Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors." Molecules 16, no. 8: 6858-6870.


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