Next Article in Journal
Seasonal Effects on Bioactive Compounds and Antioxidant Capacity of Six Economically Important Brassica Vegetables
Previous Article in Journal
HPLC and GC-MS Determination of Bioactive Compounds in Microwave Obtained Extracts of Three Varieties of Labisia pumila Benth.
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(8), 6806-6815; doi:10.3390/molecules16086806

Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds

1
Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey
2
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Bayezit, Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Received: 20 July 2011 / Revised: 2 August 2011 / Accepted: 3 August 2011 / Published: 10 August 2011
Download PDF [135 KB, uploaded 18 June 2014]   |  

Abstract

A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.
Keywords: 1,3-dioxolanes; montmorillonite K10; diols; antibacterial activity; antifungal activity 1,3-dioxolanes; montmorillonite K10; diols; antibacterial activity; antifungal activity
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Küçük, H.B.; Yusufoğlu, A.; Mataracı, E.; Döşler, S. Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules 2011, 16, 6806-6815.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top