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Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds
Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Bayezit, Istanbul, Turkey
* Author to whom correspondence should be addressed.
Received: 20 July 2011; in revised form: 2 August 2011 / Accepted: 3 August 2011 / Published: 10 August 2011
Abstract: A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.
Keywords: 1,3-dioxolanes; montmorillonite K10; diols; antibacterial activity; antifungal activity
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Küçük, H.B.; Yusufoğlu, A.; Mataracı, E.; Döşler, S. Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules 2011, 16, 6806-6815.
Küçük HB, Yusufoğlu A, Mataracı E, Döşler S. Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules. 2011; 16(8):6806-6815.
Küçük, Hatice Başpınar; Yusufoğlu, Ayşe; Mataracı, Emel; Döşler, Sibel. 2011. "Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds." Molecules 16, no. 8: 6806-6815.