Molecules 2011, 16(8), 6806-6815; doi:10.3390/molecules16086806
Article

Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds

1 Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey 2 Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Bayezit, Istanbul, Turkey
* Author to whom correspondence should be addressed.
Received: 20 July 2011; in revised form: 2 August 2011 / Accepted: 3 August 2011 / Published: 10 August 2011
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Abstract: A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.
Keywords: 1,3-dioxolanes; montmorillonite K10; diols; antibacterial activity; antifungal activity

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MDPI and ACS Style

Küçük, H.B.; Yusufoğlu, A.; Mataracı, E.; Döşler, S. Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules 2011, 16, 6806-6815.

AMA Style

Küçük HB, Yusufoğlu A, Mataracı E, Döşler S. Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules. 2011; 16(8):6806-6815.

Chicago/Turabian Style

Küçük, Hatice Başpınar; Yusufoğlu, Ayşe; Mataracı, Emel; Döşler, Sibel. 2011. "Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds." Molecules 16, no. 8: 6806-6815.

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