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Molecules 2011, 16(8), 6582-6590; doi:10.3390/molecules16086582
Article

(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

1
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1
,
1
,
2
,
3
 and
1,*
1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 31 May 2011 / Revised: 4 July 2011 / Accepted: 6 July 2011 / Published: 4 August 2011
(This article belongs to the Section Natural Products)
Download PDF [683 KB, 18 June 2014; original version 18 June 2014]

Abstract

A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 µg/mL.
Keywords: Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mollataghi, A.; Hadi, A.H.A.; Awang, K.; Mohamad, J.; Litaudon, M.; Mukhtar, M.R. (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble. Molecules 2011, 16, 6582-6590.

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