Molecules 2011, 16(8), 6582-6590; doi:10.3390/molecules16086582
Article

(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 31 May 2011; in revised form: 4 July 2011 / Accepted: 6 July 2011 / Published: 4 August 2011
(This article belongs to the Section Natural Products)
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Abstract: A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 µg/mL.
Keywords: Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant

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MDPI and ACS Style

Mollataghi, A.; Hadi, A.H.A.; Awang, K.; Mohamad, J.; Litaudon, M.; Mukhtar, M.R. (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble. Molecules 2011, 16, 6582-6590.

AMA Style

Mollataghi A, Hadi AHA, Awang K, Mohamad J, Litaudon M, Mukhtar MR. (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble. Molecules. 2011; 16(8):6582-6590.

Chicago/Turabian Style

Mollataghi, Abbas; Hadi, A Hamid A; Awang, Khalijah; Mohamad, Jamaludin; Litaudon, Marc; Mukhtar, Mat Ropi. 2011. "(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble." Molecules 16, no. 8: 6582-6590.

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