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Molecules 2011, 16(8), 6582-6590; doi:10.3390/molecules16086582
Article

(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

1
,
1
,
1
,
2
,
3
 and
1,*
1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 31 May 2011 / Revised: 4 July 2011 / Accepted: 6 July 2011 / Published: 4 August 2011
(This article belongs to the Section Natural Products)
Download PDF [683 KB, 18 June 2014; original version 18 June 2014]

Abstract

A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 µg/mL.
Keywords: Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant Beilschmiedia kunstleri; alkaloid; neolignan; lauraceae; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mollataghi, A.; Hadi, A.H.A.; Awang, K.; Mohamad, J.; Litaudon, M.; Mukhtar, M.R. (+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble. Molecules 2011, 16, 6582-6590.

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