Molecules 2011, 16(7), 6116-6128; doi:10.3390/molecules16076116
Article

Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones

1email, 1email, 2,* email and 1,* email
Received: 1 April 2011; in revised form: 5 July 2011 / Accepted: 11 July 2011 / Published: 20 July 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data.
Keywords: hydrogenation; homogeneous catalysis; ruthenium catalysts; BINAP; arylidenetetramic acid
PDF Full-text Download PDF Full-Text [481 KB, uploaded 18 June 2014 19:39 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Karaiskos, C.S.; Matiadis, D.; Markopoulos, J.; Igglessi-Markopoulou, O. Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones. Molecules 2011, 16, 6116-6128.

AMA Style

Karaiskos CS, Matiadis D, Markopoulos J, Igglessi-Markopoulou O. Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones. Molecules. 2011; 16(7):6116-6128.

Chicago/Turabian Style

Karaiskos, Christos S.; Matiadis, Dimitris; Markopoulos, John; Igglessi-Markopoulou, Olga. 2011. "Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones." Molecules 16, no. 7: 6116-6128.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert