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Molecules 2011, 16(7), 6041-6059; doi:10.3390/molecules16076041

Enzyme-Immobilized Microfluidic Process Reactors

1, 2, 1,3,4,*  and 1,3
1 Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 807-1 Shuku, Tosu, Saga 841-0052, Japan 2 Liberal Arts Education Center, Aso Campus, Tokai University, Minami-aso, Aso, Kumamoto 869 1404, Japan 3 Department of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Science, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan 4 Department of Advanced Technology Fusion, Graduate School of Science and Engineering, Saga University, 1 Honjo, Saga 840-8502, Japan
* Author to whom correspondence should be addressed.
Received: 24 June 2011 / Revised: 13 July 2011 / Accepted: 17 July 2011 / Published: 19 July 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Microreaction technology, which is an interdisciplinary science and engineering area, has been the focus of different fields of research in the past few years. Several microreactors have been developed. Enzymes are a type of catalyst, which are useful in the production of substance in an environmentally friendly way, and they also have high potential for analytical applications. However, not many enzymatic processes have been commercialized, because of problems in stability of the enzymes, cost, and efficiency of the reactions. Thus, there have been demands for innovation in process engineering, particularly for enzymatic reactions, and microreaction devices represent important tools for the development of enzyme processes. In this review, we summarize the recent advances of microchannel reaction technologies especially for enzyme immobilized microreactors. We discuss the manufacturing process of microreaction devices and the advantages of microreactors compared to conventional reaction devices. Fundamental techniques for enzyme immobilized microreactors and important applications of this multidisciplinary technology are also included in our topics.
Keywords: microfluidic reactor; microreactor; immobilization; bioconversion microfluidic reactor; microreactor; immobilization; bioconversion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Asanomi, Y.; Yamaguchi, H.; Miyazaki, M.; Maeda, H. Enzyme-Immobilized Microfluidic Process Reactors. Molecules 2011, 16, 6041-6059.

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