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Molecules 2011, 16(7), 5833-5839; doi:10.3390/molecules16075833
Article

Two New Withanolide Lactones from Flos Daturae

* , ,  and
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
* Author to whom correspondence should be addressed.
Received: 1 June 2011 / Revised: 29 June 2011 / Accepted: 5 July 2011 / Published: 11 July 2011
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Abstract

Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G (1) and baimantuoluoside H (2). Their structures were elucidated as (12β,6β,22R)-1,10-seco-6,12,27-trihydroxy-26-oxo-witha-3,5,24-trienolide-1-oic acid-ε-lactone (1) and (5β,6α,12β,22R)-5,6,12,27-tetra-hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O-β-glucopyranoside (2) on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies.
Keywords: Flos Daturae; Datura metel L.; withanolide lactones Flos Daturae; Datura metel L.; withanolide lactones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kuang, H.-X.; Yang, B.-Y.; Xia, Y.-G.; Wang, Q.-H. Two New Withanolide Lactones from Flos Daturae. Molecules 2011, 16, 5833-5839.

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