Molecules 2011, 16(7), 5754-5768; doi:10.3390/molecules16075754
Article

Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6

Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
* Author to whom correspondence should be addressed.
Received: 18 April 2011; in revised form: 23 June 2011 / Accepted: 1 July 2011 / Published: 6 July 2011
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Abstract: Adiponectin is an adipocyte-derived hormone that plays a pivotal role in the regulation of lipid and glucose metabolism. Up-regulation of adiponectin expression and production has been shown to benefit for metabolic disorders, including type 2 diabetes, hyperlipidemia, etc. The present study investigated whether the novel polymethoxylated flavonoid pentamethylquercetin (PMQ), a member of polymethoxylated flavonoids family which is present in seabuckthorn (Hippophae L.) would affect adiponectin production in differentiated 3T3-L1 adipocytes. It was found that PMQ increased the adiponectin mRNA and protein expressions in adipocytes in time- and concentration-dependent manners. The PPARγ pathway plays a important roles in this effect of PMQ because blockade of PPARγ by GW9662 eliminates the PMQ-induced up-regulation of adiponectin expression. Furthermore, significant decreases of mRNA expression and secretion of TNF-α and IL-6 were also observed in PMQ-treated cells. Taken together, our study demonstrated that PMQ up-regulates adiponectin expression via a mechanism that implicates PPARγ together with TNF-α and IL-6, suggesting that PMQ might be a potential candidate for the treatment of metabolic diseases.
Keywords: adiponectin; pentamethylquercetin (PMQ); 3T3-L1 adipocytes; PPARγ; TNF-α; IL-6

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MDPI and ACS Style

Chen, L.; He, T.; Han, Y.; Sheng, J.-Z.; Jin, S.; Jin, M.-W. Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6. Molecules 2011, 16, 5754-5768.

AMA Style

Chen L, He T, Han Y, Sheng J-Z, Jin S, Jin M-W. Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6. Molecules. 2011; 16(7):5754-5768.

Chicago/Turabian Style

Chen, Lei; He, Ting; Han, Yi; Sheng, Ji-Zhong; Jin, Si; Jin, Man-Wen. 2011. "Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6." Molecules 16, no. 7: 5754-5768.

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