Next Article in Journal
Treatment of Alcohols with Tosyl Chloride Does Not always Lead to the Formation of Tosylates
Next Article in Special Issue
Thymidine Analogues for Tracking DNA Synthesis
Previous Article in Journal
Pyranoxanthones from Mesua ferrea
Previous Article in Special Issue
Identification of N6,N6-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin
Molecules 2011, 16(7), 5655-5664; doi:10.3390/molecules16075655

NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives

1,*  and 2
1 College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China 2 Department of Chemistry, the Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
* Author to whom correspondence should be addressed.
Received: 30 May 2011 / Accepted: 10 June 2011 / Published: 1 July 2011
(This article belongs to the Special Issue Nucleoside Analogues)
Download PDF [275 KB, uploaded 18 June 2014]


5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.
Keywords: NMR; UV; 4-thiothymidine; DNA NMR; UV; 4-thiothymidine; DNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Zhang, X.; Xu, Y.-Z. NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives. Molecules 2011, 16, 5655-5664.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert