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Molecules 2011, 16(7), 5655-5664; doi:10.3390/molecules16075655

NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives

College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China
Department of Chemistry, the Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
Author to whom correspondence should be addressed.
Received: 30 May 2011 / Accepted: 10 June 2011 / Published: 1 July 2011
(This article belongs to the Special Issue Nucleoside Analogues)
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5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.
Keywords: NMR; UV; 4-thiothymidine; DNA NMR; UV; 4-thiothymidine; DNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, X.; Xu, Y.-Z. NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives. Molecules 2011, 16, 5655-5664.

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