Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Antifungal Bioassay: Inhibitory Effects on Phytopathogenic Fungi
Compd. No. | Fungicidal activities (50 μg/mL, inhibition rate %) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AK | AM | AS | BC | BM | CA | GF | GZ | MK | PI | RC | RS | SS | TC | |
1a | 45.5 | 21.4 | 41.2 | 29.6 | 34.8 | 13.3 | 20 | 25.9 | 31.3 | 22.7 | 35.0 | 63.5 | 0 | 80.4 |
1b | 18.2 | 0 | 0 | 7.4 | 17.4 | 0 | 20 | 14.8 | 31.3 | 0 | 30 | 61.9 | 0 | 3.9 |
2a | 18.2 | 0 | 0 | 40.7 | 17.4 | 0 | 20 | 0 | 46.9 | 9.1 | 5.0 | 54.0 | 20 | 2.0 |
2b | 31.8 | 21.4 | 5.9 | 37.0 | 17.4 | 13.3 | 26.7 | 29.6 | 46.9 | 0 | 5.0 | 60.3 | 0 | 2.0 |
3a | 27.3 | 21.4 | 11.8 | 7.4 | 26.1 | 33.3 | 0 | 7.4 | 21.9 | 0 | 5.0 | 57.1 | 0 | 39.2 |
3b | 63.6 | 50 | 35.3 | 25.9 | 39.1 | 46.7 | 40 | 44.4 | 25.0 | 36.4 | 25.0 | 66.7 | 0 | 76.5 |
3c | 27.3 | 21.4 | 0 | 3.7 | 13.0 | 46.7 | 13.3 | 22.2 | 0 | 36.4 | 0 | 55.6 | 33.3 | 52.9 |
4a | 40.9 | 0 | 0 | 18.5 | 17.4 | 6.7 | 6.7 | 7.4 | 31.3 | 0 | 20 | 61.9 | 0 | 19.6 |
4b | 27.3 | 21.4 | 0 | 14.8 | 13.0 | 0 | 46.7 | 14.8 | 46.9 | 18.2 | 0 | 55.6 | 40 | 15.7 |
4c | 22.7 | 21.4 | 0 | 33.3 | 26.1 | 6.7 | 53.3 | 40.7 | 37.5 | 13.6 | 0 | 61.9 | 60 | 0 |
4d | 31.8 | 28.6 | 0 | 14.8 | 26.1 | 6.7 | 20 | 7.4 | 40.6 | 13.6 | 15.0 | 63.5 | 66.7 | 9.8 |
Pyri. | 100 | 21.4 | 100 | 96.3 | 91.3 | 100 | 20 | 44.4 | 100 | 22.7 | 40 | 77.8 | 86.7 | 98.0 |
Flu. | 18.2 | 21.4 | 0 | 7.4 | 17.4 | 0 | 13.3 | 7.4 | 21.9 | 4.5 | 20 | 61.9 | 0 | 9.8 |
Dim. | 22.7 | 7.1 | 5.9 | 18.5 | 17.4 | 0 | 20 | 0 | 6.3 | 9.1 | 40 | 68.3 | 20 | 23.5 |
Carb. | 81.8 | 78.6 | 76.5 | 63.0 | 69.6 | 53.3 | 60 | 59.3 | 43.8 | 27.3 | 100 | 100 | 73.3 | 98.0 |
Hym. | 81.8 | 85.7 | 88.2 | 70.4 | 34.8 | 93.3 | 40 | 33.3 | 50 | 36.4 | 25.0 | 63.5 | 66.7 | 78.4 |
3. Experimental
3.1. General
3.2. Procedures for the Preparation of Title Compounds 1-4
4. Conclusions
Supplementary Materials
Supplementary File 1Acknowledgements
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Sun, L.; Wu, J.; Zhang, L.; Luo, M.; Sun, D. Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives. Molecules 2011, 16, 5618-5628. https://doi.org/10.3390/molecules16075618
Sun L, Wu J, Zhang L, Luo M, Sun D. Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives. Molecules. 2011; 16(7):5618-5628. https://doi.org/10.3390/molecules16075618
Chicago/Turabian StyleSun, Li, Jie Wu, Lingzi Zhang, Min Luo, and Dequn Sun. 2011. "Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives" Molecules 16, no. 7: 5618-5628. https://doi.org/10.3390/molecules16075618