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Molecules 2011, 16(7), 5550-5560; doi:10.3390/molecules16075550
Communication

An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides

, *  and *
Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est (ICMPE), UMR 7182, CNRS, Université Paris-Est Créteil Val-de-Marne, 2-8 rue Henri Dunant, 94320 Thiais, France
* Authors to whom correspondence should be addressed.
Received: 18 May 2011 / Revised: 1 June 2011 / Accepted: 21 June 2011 / Published: 29 June 2011
(This article belongs to the Special Issue Organic Electrosynthesis)
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Abstract

A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields.
Keywords: cross-coupling; electrosynthesis; functionalized pyrimidines; nickel catalysis; sacrificial anode process cross-coupling; electrosynthesis; functionalized pyrimidines; nickel catalysis; sacrificial anode process
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sengmany, S.; Le Gall, E.; Léonel, E. An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides. Molecules 2011, 16, 5550-5560.

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