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Molecules 2011, 16(7), 5550-5560; doi:10.3390/molecules16075550
Communication

An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides

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Received: 18 May 2011 / Revised: 1 June 2011 / Accepted: 21 June 2011 / Published: 29 June 2011
(This article belongs to the Special Issue Organic Electrosynthesis)
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Abstract

A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields.
Keywords: cross-coupling; electrosynthesis; functionalized pyrimidines; nickel catalysis; sacrificial anode process cross-coupling; electrosynthesis; functionalized pyrimidines; nickel catalysis; sacrificial anode process
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sengmany, S.; Le Gall, E.; Léonel, E. An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides. Molecules 2011, 16, 5550-5560.

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