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Molecules 2011, 16(7), 5527-5537; doi:10.3390/molecules16075527
Article

Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles

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Received: 24 May 2011; in revised form: 22 June 2011 / Accepted: 27 June 2011 / Published: 29 June 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract: 2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines. The starting 2-thioxo- imidazolidin-4-ones 2a,2b were prepared by condensation of thiohydantoin and benzo[b]-thiophene-3-carbaldehyde or benzofuran-3-carbaldehyde under microwave irracdiation (MW) conditions. 2-Methylthio derivatives 3a–c were prepared by treatment of 2a–b with methyl iodide in the presence of aqueous sodium hydroxide.
Keywords: MW assisted synthesis; hydantoin; arylidene-4H-imidazoles MW assisted synthesis; hydantoin; arylidene-4H-imidazoles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kamila, S.; Ankati, H.; Biehl, E.R. Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles. Molecules 2011, 16, 5527-5537.

AMA Style

Kamila S, Ankati H, Biehl ER. Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles. Molecules. 2011; 16(7):5527-5537.

Chicago/Turabian Style

Kamila, Sukanta; Ankati, Haribabu; Biehl, Edward R. 2011. "Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles." Molecules 16, no. 7: 5527-5537.



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