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Molecules 2011, 16(6), 4937-4957; doi:10.3390/molecules16064937
Article

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

1,2,* , 1,3 and 1,3
1 Department of Chemistry, Faculty of Science, Taif University, Taif, 21974, Kingdom of Saudi Arabia 2 Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44511, Egypt 3 Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt
* Author to whom correspondence should be addressed.
Received: 1 April 2011 / Revised: 25 May 2011 / Accepted: 3 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract

Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
Keywords: 1,2,4-triazinone; thiadiazinone; triazinone; triazine carbonitrile; microwave synthesis 1,2,4-triazinone; thiadiazinone; triazinone; triazine carbonitrile; microwave synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saad, H.A.; Youssef, M.M.; Mosselhi, M.A. Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity. Molecules 2011, 16, 4937-4957.

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