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Molecules 2011, 16(6), 4937-4957; doi:10.3390/molecules16064937

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

1
Department of Chemistry, Faculty of Science, Taif University, Taif, 21974, Kingdom of Saudi Arabia
2
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44511, Egypt
3
Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt
*
Author to whom correspondence should be addressed.
Received: 1 April 2011 / Revised: 25 May 2011 / Accepted: 3 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract

Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
Keywords: 1,2,4-triazinone; thiadiazinone; triazinone; triazine carbonitrile; microwave synthesis 1,2,4-triazinone; thiadiazinone; triazinone; triazine carbonitrile; microwave synthesis
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Saad, H.A.; Youssef, M.M.; Mosselhi, M.A. Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity. Molecules 2011, 16, 4937-4957.

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