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Molecules 2011, 16(6), 4389-4400; doi:10.3390/molecules16064389

In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer

1
Department of Oncology, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, China
2
Department of General Surgery, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710004, China
*
Authors to whom correspondence should be addressed.
Received: 24 March 2011 / Revised: 10 May 2011 / Accepted: 23 May 2011 / Published: 27 May 2011
(This article belongs to the Section Natural Products)
Download PDF [625 KB, 18 June 2014; original version 18 June 2014]

Abstract

In the present study, we investigated the in vitro and in vivo antitumor effects of crude extract of Scutellaria barbate (CE-SB) on mouse hepatoma H22 cells. The MTT assay was used to determine the growth inhibition of H22 cells in vitro. The in vivo therapeutic effects of CE-SB were determined using H22 tumor bearing mice. Besides, the body weight, tumor weight, thymus index and spleen index of H22 bearing mice were also measured. The tumor inhibitory rate (IR) was calculated according to the mean weight of tumor (MWT). The phagocytotic function of macrophages was examined by observing peritoneal macrophages phagocytize chicken RBC. The results showed that CE-SB could inhibit the growth of hepatoma H22 Cells in vitro and in vivo. Furthermore, CE-SB could improve immune function of H22 tumor bearing mice. Together these results indicate that CE-SB has antitumor activity and seems to be safe and effective for the use of anti-tumor therapy.
Keywords: anti-tumor; Scutellaria barbate; hepatoma; immune function; mice anti-tumor; Scutellaria barbate; hepatoma; immune function; mice
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dai, Z.-J.; Gao, J.; Li, Z.-F.; Ji, Z.-Z.; Kang, H.-F.; Guan, H.-T.; Diao, Y.; Wang, B.-F.; Wang, X.-J. In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer. Molecules 2011, 16, 4389-4400.

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