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Molecules 2011, 16(6), 4339-4347; doi:10.3390/molecules16064339
Article

Synthesis, Characterization, and Antimicrobial Evaluation of Oxadiazole Congeners

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Received: 13 April 2011; in revised form: 10 May 2011 / Accepted: 19 May 2011 / Published: 25 May 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl substituent. The structures of the synthesized compounds were confirmed by MS, 1H-NMR, and elemental analysis. In vitro antimicrobial activity for all the newly synthesized compounds at concentrations of 200-25 μg/mL was evaluated against Gram+ve organisms such as methicillin-resistant Staphylococcus aureus (MRSA), Gram–ve organisms such as Escherichia coli (E. coli), and the fungal strain Aspergillus niger (A. niger) by the cup plate method. Ofloxacin and ketoconazole (10 μg/mL) were used as reference standards for antibacterial and antifungal activity, respectively. Compounds 15, 16, and 20 showed notable antibacterial and antifungal activities at higher concentrations (200 μg/mL), whereas 17-19 were found to display significant antibacterial or antifungal activity (25-50 μg/mL) against the Gram+ve, Gram–ve bacteria, or fungal cells used in the present study.
Keywords: 1,3-oxazole; oxadiazole congeners; 1,3-thiazole; tetrazole; antibacterial; antifungal 1,3-oxazole; oxadiazole congeners; 1,3-thiazole; tetrazole; antibacterial; antifungal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sadek, B.; Fahelelbom, K.M.S. Synthesis, Characterization, and Antimicrobial Evaluation of Oxadiazole Congeners. Molecules 2011, 16, 4339-4347.

AMA Style

Sadek B, Fahelelbom KMS. Synthesis, Characterization, and Antimicrobial Evaluation of Oxadiazole Congeners. Molecules. 2011; 16(6):4339-4347.

Chicago/Turabian Style

Sadek, Bassem; Fahelelbom, Khairi Mustafa Salem. 2011. "Synthesis, Characterization, and Antimicrobial Evaluation of Oxadiazole Congeners." Molecules 16, no. 6: 4339-4347.


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