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Antioxidant and Cytotoxic Constituents from Wisteria sinensis
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt
* Author to whom correspondence should be addressed.
Received: 5 February 2011; in revised form: 13 May 2011 / Accepted: 16 May 2011 / Published: 17 May 2011
Abstract: Chromatographic separation of an aqueous MeOH extract of Wisteria sinensis leaves has yielded six known flavonoids, two triterpene aglycones and the new acylated flavone glycoside chrysoeriol-7-O-[2''-O-(5'''-O-caffeoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside (1). All metabolites were isolated for the first time from the genus Wisteria. Their structures were established on the basis of their chromatographic properties, chemical and physicochemical methods including acid hydrolysis analysis, spectroscopic (UV, 1H- and 13C-NMR) data and confirmed by ESI-MS analysis, as well as two-dimensional NMR (1H-1HCOSY, HMQC and HMBC). Biological studies of the defatted aqueous 80% methanol leaf extract and the major isolates 1, 6 and 7 were undertaken and they are reported herein for the first time to have significant cytotoxic activity against the Hep-G2 tumor cell line in addition to antioxidant activity.
Keywords: Wisteria sinensis; fabeaceae; acylated flavone; cytotoxic; Hep-G2
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Mohamed, M.A.; Hamed, M.M.; Abdou, A.M.; Ahmed, W.S.; Saad, A.M. Antioxidant and Cytotoxic Constituents from Wisteria sinensis. Molecules 2011, 16, 4020-4030.
Mohamed MA, Hamed MM, Abdou AM, Ahmed WS, Saad AM. Antioxidant and Cytotoxic Constituents from Wisteria sinensis. Molecules. 2011; 16(5):4020-4030.
Mohamed, Mona A.; Hamed, Manal M.; Abdou, Allia M.; Ahmed, Wafaa S.; Saad, Amal M. 2011. "Antioxidant and Cytotoxic Constituents from Wisteria sinensis." Molecules 16, no. 5: 4020-4030.