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Molecules 2011, 16(5), 4020-4030; doi:10.3390/molecules16054020

Antioxidant and Cytotoxic Constituents from Wisteria sinensis

* ,
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt
* Author to whom correspondence should be addressed.
Received: 5 February 2011 / Revised: 13 May 2011 / Accepted: 16 May 2011 / Published: 17 May 2011
(This article belongs to the Section Medicinal Chemistry)
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Chromatographic separation of an aqueous MeOH extract of Wisteria sinensis leaves has yielded six known flavonoids, two triterpene aglycones and the new acylated flavone glycoside chrysoeriol-7-O-[2''-O-(5'''-O-caffeoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside (1). All metabolites were isolated for the first time from the genus Wisteria. Their structures were established on the basis of their chromatographic properties, chemical and physicochemical methods including acid hydrolysis analysis, spectroscopic (UV, 1H- and 13C-NMR) data and confirmed by ESI-MS analysis, as well as two-dimensional NMR (1H-1HCOSY, HMQC and HMBC). Biological studies of the defatted aqueous 80% methanol leaf extract and the major isolates 1, 6 and 7 were undertaken and they are reported herein for the first time to have significant cytotoxic activity against the Hep-G2 tumor cell line in addition to antioxidant activity.
Keywords: Wisteria sinensis; fabeaceae; acylated flavone; cytotoxic; Hep-G2 Wisteria sinensis; fabeaceae; acylated flavone; cytotoxic; Hep-G2
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mohamed, M.A.; Hamed, M.M.; Abdou, A.M.; Ahmed, W.S.; Saad, A.M. Antioxidant and Cytotoxic Constituents from Wisteria sinensis. Molecules 2011, 16, 4020-4030.

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