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Molecules 2011, 16(5), 3875-3884; doi:10.3390/molecules16053875
Article

Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder

1,3, 1,3, 1,3, 1,3, 2,3, 2,3, 1,3,*  and 1,3,*
Received: 12 February 2010 / Revised: 28 April 2011 / Accepted: 6 May 2011 / Published: 9 May 2011
(This article belongs to the Section Metabolites)
Download PDF [379 KB, 18 June 2014; original version 18 June 2014]

Abstract

Gaultheria yunnanensis (Franch.) Rehder is a kind of traditional Chinese herbal medicine used for the treatments of rheumatoid arthritis, swelling and pain. Two methyl salicylate glycosides, namely methyl benzoate-2-O-b-D-xylopyranosyl(1-6)-O-b-D-gluco-pyranoside (J12122) and methyl benzoate-2-O-β-D-xylopyranosyl(1-2)[O-β-D-xylopyranosyl(1-6)]-O-β-D-glucopyranoside (J12123), are natural salicylic derivatives isolated from Gaultheria yunnanensis. In this study, we investigated the anti-inflammatory activity of J12122 and J12123 on LPS-induced RAW264.7 macrophage cells by measuring the production of pro-inflammatory cytokines, accumulation of nitric oxide (NO), and level of reactive oxygen species (ROS). The results showed that both methyl salicylate glycosides dose-dependently inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, respectively. Consistent with these observations, J12122 and J12123 significantly suppressed the accumulation of NO, with an inhibitory rate of 56.20% and 51.72% at 3.0 μg/mL concentration, respectively. Furthermore, the two methyl salicylate glycosides reduced the level of ROS induced by LPS. These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS.
Keywords: Gaultheria plant; anti-inflammation; methyl salicylicate glycoside; inflammatory cytokines Gaultheria plant; anti-inflammation; methyl salicylicate glycoside; inflammatory cytokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, D.; Liu, R.; Sun, L.; Huang, C.; Wang, C.; Zhang, D.-M.; Zhang, T.-T.; Du, G.-H. Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder. Molecules 2011, 16, 3875-3884.

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