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Molecules 2011, 16(4), 2862-2870; doi:10.3390/molecules16042862

Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties

1
Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan
2
Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan
3
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan
4
Department of Chemistry, Faculty of Sciences, University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 18 February 2011 / Revised: 21 March 2011 / Accepted: 28 March 2011 / Published: 31 March 2011
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Abstract

Zinc- and silver-doped mullite ceramic discs were prepared and tested as potentially resistant materials against bacterial adhesion and biofilm formation. Elemental analysis and X-ray diffraction studies showed that zinc ions were incorporated in the structural framework of the mullite, while silver ions remained outside the mullite crystal lattice, which allowed their slow (0.02 ppm/24 hours) leaching into the surrounding aqueous environment. In agreement with this behavior, silver-doped mullite showed potent resistance against surface attachment of Pseudomonas aeruginosa, while on the other hand, zinc-doped mullite failed to stop bacterial attachment.
Keywords: mullite; silver; zinc; bacterial attachment; Pseudomonas aeruginosa mullite; silver; zinc; bacterial attachment; Pseudomonas aeruginosa
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Saleh, S.; Taha, M.O.; Haddadin, R.N.; Marzooqa, D.; Hodali, H. Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties. Molecules 2011, 16, 2862-2870.

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