Molecules 2011, 16(4), 2862-2870; doi:10.3390/molecules16042862
Article

Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties

1 Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan 2 Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan 3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan 4 Department of Chemistry, Faculty of Sciences, University of Jordan, Amman, Jordan
* Author to whom correspondence should be addressed.
Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 28 March 2011 / Published: 31 March 2011
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Abstract: Zinc- and silver-doped mullite ceramic discs were prepared and tested as potentially resistant materials against bacterial adhesion and biofilm formation. Elemental analysis and X-ray diffraction studies showed that zinc ions were incorporated in the structural framework of the mullite, while silver ions remained outside the mullite crystal lattice, which allowed their slow (0.02 ppm/24 hours) leaching into the surrounding aqueous environment. In agreement with this behavior, silver-doped mullite showed potent resistance against surface attachment of Pseudomonas aeruginosa, while on the other hand, zinc-doped mullite failed to stop bacterial attachment.
Keywords: mullite; silver; zinc; bacterial attachment; Pseudomonas aeruginosa

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MDPI and ACS Style

Saleh, S.; Taha, M.O.; Haddadin, R.N.; Marzooqa, D.; Hodali, H. Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties. Molecules 2011, 16, 2862-2870.

AMA Style

Saleh S, Taha MO, Haddadin RN, Marzooqa D, Hodali H. Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties. Molecules. 2011; 16(4):2862-2870.

Chicago/Turabian Style

Saleh, Suhair; Taha, Mutasem O.; Haddadin, Randa N.; Marzooqa, Duá; Hodali, Hamdallah. 2011. "Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties." Molecules 16, no. 4: 2862-2870.

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