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Molecules 2011, 16(3), 2274-2284; doi:10.3390/molecules16032274
Article

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

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Received: 28 January 2011 / Revised: 2 March 2011 / Accepted: 4 March 2011 / Published: 7 March 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.
Keywords: combretastatin analogs; multidrug-resistant; trimethoxyquinolines; antiproliferative activity combretastatin analogs; multidrug-resistant; trimethoxyquinolines; antiproliferative activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hsieh, C.-C.; Lee, H.-Y.; Nien, C.-Y.; Kuo, C.-C.; Chang, C.-Y.; Chang, J.-Y.; Liou, J.-P. Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents. Molecules 2011, 16, 2274-2284.

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