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Potent Anti-Platelet Constituents from Centaurea iberica
International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
Riphah Institute of Pharmaceutical Sciences, Riphah International University, 7th Avenue, G-7/4 Islamabad, Pakistan
International Centre for Chemical and Biological Sciences, Dr. Panjwani Centre for Molecular Medicine and Drug Research, University of Karachi, Karachi 75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 3 January 2011; in revised form: 24 February 2011 / Accepted: 26 February 2011 / Published: 28 February 2011
Abstract: New naturally occurring nitrogenous compounds 1 and 2, along with a new dimeric lignan glucoside 3, have been isolated from the ethyl acetate soluble fraction of Centaurea iberica. Their structures have been elucidated through spectroscopic techniques. All the isolated compounds showed significant platelet aggregation inhibition.
Keywords: Centaurea iberica; nitrogenous compounds; dimeric lignan glucoside; anti platelet activity
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Khan, A.N.; Fatima, I.; Khaliq, U.A.; Malik, A.; Miana, G.A.; Qureshi, Z.-U.-R.; Rasheed, H. Potent Anti-Platelet Constituents from Centaurea iberica. Molecules 2011, 16, 2053-2064.
Khan AN, Fatima I, Khaliq UA, Malik A, Miana GA, Qureshi Z-U-R, Rasheed H. Potent Anti-Platelet Constituents from Centaurea iberica. Molecules. 2011; 16(3):2053-2064.
Khan, Amna Nisar; Fatima, Itrat; Khaliq, Urooj Abdul; Malik, Abdul; Miana, Ghulam Abbas; Qureshi, Zia-ur-Rehman; Rasheed, Huma. 2011. "Potent Anti-Platelet Constituents from Centaurea iberica." Molecules 16, no. 3: 2053-2064.