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Molecules 2011, 16(2), 1642-1654; doi:10.3390/molecules16021642
Article

Peppermint Oil Decreases the Production of Virulence-Associated Exoproteins by Staphylococcus aureus

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Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 November 2010 / Revised: 8 February 2011 / Accepted: 10 February 2011 / Published: 15 February 2011
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Abstract

The present study aimed to evaluate the antimicrobial activity of peppermint oil against Staphylococcus aureus, and further investigate the influence of peppermint oil on S. aureus virulence-related exoprotein production. The data show that peppermint oil, which contained high contents of menthone, isomenthone, neomenthol, menthol, and menthyl acetate, was active against S. aureus with minimal inhibitory concentrations (MICs) ranging from 64-256 µg/mL, and the production of S. aureus exotoxins was decreased by subinhibitory concentrations of peppermint oil in a dose-dependent manner. The findings suggest that peppermint oil may potentially be used to aid in the treatment of S. aureus infections.
Keywords: Staphylococcus aureus; peppermint oil; α-toxin; staphylococcal enterotoxins; toxic shock syndrome toxin 1 Staphylococcus aureus; peppermint oil; α-toxin; staphylococcal enterotoxins; toxic shock syndrome toxin 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, J.; Dong, J.; Qiu, J.-Z.; Wang, J.-F.; Luo, M.-J.; Li, H.-E.; Leng, B.-F.; Ren, W.-Z.; Deng, X.-M. Peppermint Oil Decreases the Production of Virulence-Associated Exoproteins by Staphylococcus aureus. Molecules 2011, 16, 1642-1654.

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