Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

doi:10.3390/molecules16129886

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Molecules 2011, 16(12), 9886-9899; doi:10.3390/molecules16129886

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Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

Eunyoung Lim, Jeremy Ricci and Mankil Jung*

Department of Chemistry, Yonsei University, Seoul 120-749, Korea

* Author to whom correspondence should be addressed.

Received: 1 November 2011; in revised form: 18 November 2011 / Accepted: 22 November 2011 / Published: 28 November 2011

(This article belongs to the Section Organic Synthesis)

Download PDF Full-Text [426 KB, uploaded 28 November 2011 13:58 CET]

Abstract: Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.

Keywords: dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe

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MDPI and ACS Style

Lim, E.; Ricci, J.; Jung, M. Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties. Molecules 2011, 16, 9886-9899.

AMA Style

Lim E, Ricci J, Jung M. Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties. Molecules. 2011; 16(12):9886-9899.

Chicago/Turabian Style

Lim, Eunyoung; Ricci, Jeremy; Jung, Mankil. 2011. "Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties." Molecules 16, no. 12: 9886-9899.

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