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Molecules 2011, 16(12), 9886-9899; doi:10.3390/molecules16129886
Article

Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

,  and *
Department of Chemistry, Yonsei University, Seoul 120-749, Korea
* Author to whom correspondence should be addressed.
Received: 1 November 2011 / Revised: 18 November 2011 / Accepted: 22 November 2011 / Published: 28 November 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.
Keywords: dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lim, E.; Ricci, J.; Jung, M. Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties. Molecules 2011, 16, 9886-9899.

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