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Molecules 2011, 16(12), 9886-9899; doi:10.3390/molecules16129886
Article

Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

,  and *
Received: 1 November 2011 / Revised: 18 November 2011 / Accepted: 22 November 2011 / Published: 28 November 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.
Keywords: dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lim, E.; Ricci, J.; Jung, M. Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties. Molecules 2011, 16, 9886-9899.

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