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Molecules 2011, 16(12), 10479-10490; doi:10.3390/molecules161210479

Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity

1, 2, 1, 2, 2 and 1,*
1 Department of Biological Sciences, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP, 14801-902, Araraquara, SP, Brazil 2 Department of Organic Chemistry, Chemistry Institute, São Paulo State University-UNESP, 14800-900, Araraquara, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 1 November 2011 / Revised: 1 December 2011 / Accepted: 5 December 2011 / Published: 16 December 2011
(This article belongs to the Section Natural Products)
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Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin-6-C-b-D-glucopyranoside (1), 7-methoxyluteolin-6-C-b-D-glucopyranoside (2), 7-methoxyluteolin-8-C-b-D-glucopyranoside (3), 4′-methoxyluteolin-6-C-b-D-glucopyranoside (4), and 6-hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxy-methyl-1,3,5,6-tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated compounds of the leaves of L. spiralis were assayed against Gram-positive (Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella setubal and Helicobacter pylori) and fungi (the yeasts Candida albicans, C. tropicalis, C. krusei and C. parapsilosis). We observed the best minimum inhibitory concentration values for the methanolic extract against Candida parapsilosis, for the fraction 5 + 6 against Gram-negative bacteria E. coli and P. aeruginosa, and compound 7 against all tested Candida strains. The methanolic extract contents suggest that this species may be a promising source of compounds to produce natural phytomedicines.
Keywords: Eriocaulaceae; Leiothrix spiralis; phenolic compounds; antimicrobial activity Eriocaulaceae; Leiothrix spiralis; phenolic compounds; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Araújo, M.G.F.; Hilário, F.; Nogueira, L.G.; Vilegas, W.; Santos, L.C.; Bauab, T.M. Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity. Molecules 2011, 16, 10479-10490.

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