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Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities
College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia
Received: 11 November 2011; in revised form: 28 November 2011 / Accepted: 29 November 2011 / Published: 12 December 2011
Abstract: A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
Keywords: coumarin derivatives; chalcone; antioxidant activities
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MDPI and ACS Style
Al-Ayed, A.S. Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities. Molecules 2011, 16, 10292-10302.
Al-Ayed AS. Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities. Molecules. 2011; 16(12):10292-10302.
Al-Ayed, Abdullah Sulaiman. 2011. "Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities." Molecules 16, no. 12: 10292-10302.