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Molecules 2011, 16(12), 10292-10302; doi:10.3390/molecules161210292
Article

Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities

Received: 11 November 2011; in revised form: 28 November 2011 / Accepted: 29 November 2011 / Published: 12 December 2011
(This article belongs to the Special Issue Stereoselective Synthesis)
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Abstract: A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
Keywords: coumarin derivatives; chalcone; antioxidant activities coumarin derivatives; chalcone; antioxidant activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Ayed, A.S. Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities. Molecules 2011, 16, 10292-10302.

AMA Style

Al-Ayed AS. Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities. Molecules. 2011; 16(12):10292-10302.

Chicago/Turabian Style

Al-Ayed, Abdullah Sulaiman. 2011. "Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities." Molecules 16, no. 12: 10292-10302.


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