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Molecules 2011, 16(11), 9386-9396; doi:10.3390/molecules16119386
Article

Antimicrobial Prospect of Newly Synthesized 1,3-Thiazole Derivatives

1,* , 2 and 2
Received: 8 October 2011 / Revised: 31 October 2011 / Accepted: 7 November 2011 / Published: 9 November 2011
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Abstract

A new series of 1,3-thiazole and benzo[d]thiazole derivatives 10–15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25–200 μg/mL against Gram+ve organisms such as methicillin-resistant Staphylococcus aureus (MRSA), Gram–ve organisms such as Escherichia coli (E. coli), and the fungal strain Aspergillus niger (A. niger) by the cup plate method. Ofloxacin and ketoconazole (10 μg/mL) were used as reference standards for antibacterial and antifungal activity, respectively. Compounds 11 and 12 showed notable antibacterial and antifungal activities at higher concentrations (125–200 μg/mL), whereas benzo[d]thiazole derivatives 13 and 14 were found to display significant antibacterial or antifungal activity (50–75 μg/mL) against the Gram+ve, Gram–ve bacteria, or fungal cells used in the present study. In addition, a correlation between calculated and determined partition coefficient (log P) was established which allows future development of compounds within this series to be carried out based on calculated log P values. Moreover, compounds 13 and 14 show that the optimum logarithm of partition coefficient (log P) should be around 4.
Keywords: synthesis; antimicrobial evaluation; 1,3-thiazoles; benzo[d]thiazoles; partition coefficient synthesis; antimicrobial evaluation; 1,3-thiazoles; benzo[d]thiazoles; partition coefficient
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sadek, B.; Al-Tabakha, M.M.; Fahelelbom, K.M.S. Antimicrobial Prospect of Newly Synthesized 1,3-Thiazole Derivatives. Molecules 2011, 16, 9386-9396.

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