Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies

doi:10.3390/molecules16108257

This article is

freely available
re-usable

Molecules 2011, 16(10), 8257-8272; doi:10.3390/molecules16108257

Article

Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies

Xiaowu Dong¹, Yanming Wang¹, Tao Liu¹, Peng Wu¹, Jiadi Gao¹, Jianchao Xu¹, Bo Yang² and Yongzhou Hu^1,*

¹ ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China ² Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China

* Author to whom correspondence should be addressed.

Received: 29 July 2011; in revised form: 14 September 2011 / Accepted: 16 September 2011 / Published: 28 September 2011

Download PDF Full-Text [638 KB, uploaded 28 September 2011 14:46 CEST]

Abstract: A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a–g were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pretreated with 1 μM phenylephrine (PE). Several compounds showed potent vasorelaxant activities. Compound 10a (EC₅₀ = 7.6 μM, E_max = 93.1%), the most potent one, would be a promising structural template for development of novel and more efficient vasodilators. Further, 2D-QSAR analysis of compounds 10a,b and 11c-e as well as thirty previously synthesized flavonoids 1-3 and 12-38 using Enhanced Replacement Method-Multiple Linear Regression (ERM-MLR) was further performed based on an optimal set of molecular descriptors (H5m, SIC2, DISPe, Mor03u and L3m), leading to a reliable model with good predictive ability (R_train² = 0.839, Q_loo² = 0.733 and R_test² = 0.804). The results provide good insights into the structure- activity relationships of the target compounds.

Keywords: flavonoids; molecular descriptors; vasorelaxant agents; qsar; erm-mlr

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Dong, X.; Wang, Y.; Liu, T.; Wu, P.; Gao, J.; Xu, J.; Yang, B.; Hu, Y. Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies. Molecules 2011, 16, 8257-8272.

AMA Style

Dong X, Wang Y, Liu T, Wu P, Gao J, Xu J, Yang B, Hu Y. Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies. Molecules. 2011; 16(10):8257-8272.

Chicago/Turabian Style

Dong, Xiaowu; Wang, Yanming; Liu, Tao; Wu, Peng; Gao, Jiadi; Xu, Jianchao; Yang, Bo; Hu, Yongzhou. 2011. "Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies." Molecules 16, no. 10: 8257-8272.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert