Next Article in Journal
Synthesis of a Dehydroabietyl Derivative Bearing a 2-(2′-Hydroxyphenyl) Benzimidazole Unit and Its Selective Cu2+ Chemosensing
Previous Article in Journal
Effect of Five Different Stages of Ripening on Chemical Compounds in Medlar (Mespilus germanica L.)
Molecules 2011, 16(1), 92-99; doi:10.3390/molecules16010092
Article

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

1, 1, 1,2, 2,3, 3 and 1,*
1 Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria 2 Center of Research in Physical and Chemical Analysis CRAPC, BP 248, Algiers RP 16004, Algiers, Algeria 3 Laboratory of Natural Gas, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar 16111, Algiers, Algeria
* Author to whom correspondence should be addressed.
Received: 19 November 2010 / Accepted: 11 December 2010 / Published: 28 December 2010
Download PDF [118 KB, uploaded 18 June 2014]
SciFeed

Abstract

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.
Keywords: 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Kaoua, R.; Bennamane, N.; Bakhta, S.; Benadji, S.; Rabia, C.; Nedjar-Kolli, B. Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure. Molecules 2011, 16, 92-99.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert