Molecules 2011, 16(1), 92-99; doi:10.3390/molecules16010092
Article

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

1, 1, 1,2, 2,3, 3 and 1,* email
Received: 19 November 2010; Accepted: 11 December 2010 / Published: 28 December 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.
Keywords: 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids
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MDPI and ACS Style

Kaoua, R.; Bennamane, N.; Bakhta, S.; Benadji, S.; Rabia, C.; Nedjar-Kolli, B. Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure. Molecules 2011, 16, 92-99.

AMA Style

Kaoua R, Bennamane N, Bakhta S, Benadji S, Rabia C, Nedjar-Kolli B. Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure. Molecules. 2011; 16(1):92-99.

Chicago/Turabian Style

Kaoua, Rachedine; Bennamane, Norah; Bakhta, Saliha; Benadji, Sihame; Rabia, Cherifa; Nedjar-Kolli, Bellara. 2011. "Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure." Molecules 16, no. 1: 92-99.


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