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Molecules 2011, 16(1), 92-99; doi:10.3390/molecules16010092

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

1
Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria
2
Center of Research in Physical and Chemical Analysis CRAPC, BP 248, Algiers RP 16004, Algiers, Algeria
3
Laboratory of Natural Gas, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar 16111, Algiers, Algeria
*
Author to whom correspondence should be addressed.
Received: 19 November 2010 / Accepted: 11 December 2010 / Published: 28 December 2010
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Abstract

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.
Keywords: 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kaoua, R.; Bennamane, N.; Bakhta, S.; Benadji, S.; Rabia, C.; Nedjar-Kolli, B. Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure. Molecules 2011, 16, 92-99.

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