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Molecules 2011, 16(1), 92-99; doi:10.3390/molecules16010092
Article

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

1, 1, 1,2, 2,3, 3 and 1,*
Received: 19 November 2010 / Accepted: 11 December 2010 / Published: 28 December 2010
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Abstract

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.
Keywords: 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids 1,4-diazepine; 1,5-benzodiazepine; dehydroacetic acid; 1,3-aminomethyl propane; orthophenylene diamine; heteropolyacids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kaoua, R.; Bennamane, N.; Bakhta, S.; Benadji, S.; Rabia, C.; Nedjar-Kolli, B. Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure. Molecules 2011, 16, 92-99.

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