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Molecules 2011, 16(1), 319-335; doi:10.3390/molecules16010319
Article

Synthesis, Molecular Structure, Spectral Properties and Antifungal Activity of Polymethylene-α,ω-bis(N,N- dimethyl-N-dodecyloammonium Bromides)

1,* , 1 and 2
Received: 22 December 2010 / Revised: 27 December 2010 / Accepted: 4 January 2011 / Published: 5 January 2011
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Abstract

Hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide) (1), pentamethylene-1,5-bis(N,N-dimethyl-N-dodecylammonium bromide) (2), tetramethylene-1,4-bis(N,N-dimethyl-N-dodecylammonium bromide) (3), trimethylene-1,3-bis(N,N-dimethyl-N-dodecylammonium bromide) (4) and ethylene-1,2-bis(N,N-dimethyl-N-dodecylammonium bromide) (5) have been obtained and characterized by FTIR and NMR spectroscopy. DFT calculations have also been carried out. The optimized bond lengths, bond angles and torsion angles calculated by Hartree-Fock/3-21G(d,p) approach have been presented. MIC values for A. niger, P. chrysogenum, C. albicans have been determined and the relationship between MIC and spacer length has been discussed.
Keywords: polymethylene-α,ω-bis(N,N-dimethyl-N-dodecyloammonium bromides); FTIR and NMR spectra; DFT calculations; antifungal activity polymethylene-α,ω-bis(N,N-dimethyl-N-dodecyloammonium bromides); FTIR and NMR spectra; DFT calculations; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brycki, B.; Kowalczyk, I.; Kozirog, A. Synthesis, Molecular Structure, Spectral Properties and Antifungal Activity of Polymethylene-α,ω-bis(N,N- dimethyl-N-dodecyloammonium Bromides). Molecules 2011, 16, 319-335.

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