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Molecules 2011, 16(1), 319-335; doi:10.3390/molecules16010319
Article

Synthesis, Molecular Structure, Spectral Properties and Antifungal Activity of Polymethylene-α,ω-bis(N,N- dimethyl-N-dodecyloammonium Bromides)

1,* , 1 and 2
1 Laboratory of Microbiocides Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland 2 Institute of Fermentation Technology and Microbiology, Technical University of Lodz, Wolczanska 171/173, 90-924 Lodz, Poland
* Author to whom correspondence should be addressed.
Received: 22 December 2010 / Revised: 27 December 2010 / Accepted: 4 January 2011 / Published: 5 January 2011
Download PDF [425 KB, 18 June 2014; original version 18 June 2014]

Abstract

Hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide) (1), pentamethylene-1,5-bis(N,N-dimethyl-N-dodecylammonium bromide) (2), tetramethylene-1,4-bis(N,N-dimethyl-N-dodecylammonium bromide) (3), trimethylene-1,3-bis(N,N-dimethyl-N-dodecylammonium bromide) (4) and ethylene-1,2-bis(N,N-dimethyl-N-dodecylammonium bromide) (5) have been obtained and characterized by FTIR and NMR spectroscopy. DFT calculations have also been carried out. The optimized bond lengths, bond angles and torsion angles calculated by Hartree-Fock/3-21G(d,p) approach have been presented. MIC values for A. niger, P. chrysogenum, C. albicans have been determined and the relationship between MIC and spacer length has been discussed.
Keywords: polymethylene-α,ω-bis(N,N-dimethyl-N-dodecyloammonium bromides); FTIR and NMR spectra; DFT calculations; antifungal activity polymethylene-α,ω-bis(N,N-dimethyl-N-dodecyloammonium bromides); FTIR and NMR spectra; DFT calculations; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Brycki, B.; Kowalczyk, I.; Kozirog, A. Synthesis, Molecular Structure, Spectral Properties and Antifungal Activity of Polymethylene-α,ω-bis(N,N- dimethyl-N-dodecyloammonium Bromides). Molecules 2011, 16, 319-335.

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