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Molecules 2010, 15(9), 6559-6569; doi:10.3390/molecules15096559
Article

Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones

1,* , 1
 and 2
Received: 23 August 2010; in revised form: 7 September 2010 / Accepted: 16 September 2010 / Published: 20 September 2010
(This article belongs to the collection Bioactive Compounds)
Download PDF [2862 KB, uploaded 18 June 2014]
Abstract: To search for possible anti-tumor agents or anti-tumor promoters among natural or synthetic products, we used cyclic voltammetry to determine the reduction-oxidation potentials of heterocyclic quinones in phosphate buffer at pH 7.2. We determined the growth inhibitory- and cytotoxic activities of 12 heterocyclic quinone anti-tumor agent candidates against a panel of 39 human cancer cell lines (JFCR39). The average concentrations of the heterocyclic quinones required for 50% growth inhibition (GI50) against JFCR39 ranged from 0.045 to 13.2 µM, and the 50% lethal concentration (LC50) against JFCR39 ranged from 0.398 to 77.7 µM. The average values of GI50 or LC50 of the heterocyclic quinones correlated significantly with their reduction potentials. These results suggested that reduction-oxidation potentials could be a useful method for the discovery of novel antitumor agents.
Keywords: human cancer cell lines; heterocyclic quinone; reduction potential; cyclic voltammetry human cancer cell lines; heterocyclic quinone; reduction potential; cyclic voltammetry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Koyama, J.; Morita, I.; Yamori, T. Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones. Molecules 2010, 15, 6559-6569.

AMA Style

Koyama J, Morita I, Yamori T. Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones. Molecules. 2010; 15(9):6559-6569.

Chicago/Turabian Style

Koyama, Junko; Morita, Izumi; Yamori, Takao. 2010. "Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones." Molecules 15, no. 9: 6559-6569.


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