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Molecules 2010, 15(9), 6019-6034; doi:10.3390/molecules15096019

Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

, ,  and *
Department of Chemistry, Umeå University, SE-90187, Umeå, Sweden
* Author to whom correspondence should be addressed.
Received: 6 July 2010 / Revised: 26 August 2010 / Accepted: 30 August 2010 / Published: 31 August 2010
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A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
Keywords: type III secretion; Suzuki coupling; Grignard addition type III secretion; Suzuki coupling; Grignard addition
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hillgren, J.M.; Dahlgren, M.K.; To, T.M.; Elofsson, M. Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides. Molecules 2010, 15, 6019-6034.

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