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Molecules 2010, 15(9), 6019-6034; doi:10.3390/molecules15096019
Article

Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

, ,  and *
Received: 6 July 2010; in revised form: 26 August 2010 / Accepted: 30 August 2010 / Published: 31 August 2010
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Abstract: A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
Keywords: type III secretion; Suzuki coupling; Grignard addition type III secretion; Suzuki coupling; Grignard addition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hillgren, J.M.; Dahlgren, M.K.; To, T.M.; Elofsson, M. Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides. Molecules 2010, 15, 6019-6034.

AMA Style

Hillgren JM, Dahlgren MK, To TM, Elofsson M. Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides. Molecules. 2010; 15(9):6019-6034.

Chicago/Turabian Style

Hillgren, J. Mikael; Dahlgren, Markus K.; To, Tam M.; Elofsson, Mikael. 2010. "Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides." Molecules 15, no. 9: 6019-6034.


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