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Molecules 2010, 15(9), 6019-6034; doi:10.3390/molecules15096019

Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

Department of Chemistry, Umeå University, SE-90187, Umeå, Sweden
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Received: 6 July 2010 / Revised: 26 August 2010 / Accepted: 30 August 2010 / Published: 31 August 2010
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Abstract

A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
Keywords: type III secretion; Suzuki coupling; Grignard addition type III secretion; Suzuki coupling; Grignard addition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hillgren, J.M.; Dahlgren, M.K.; To, T.M.; Elofsson, M. Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides. Molecules 2010, 15, 6019-6034.

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