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Molecules 2010, 15(7), 4784-4791; doi:10.3390/molecules15074784
Communication

Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents

1,2 and 1,*
Received: 13 May 2010; in revised form: 28 May 2010 / Accepted: 9 June 2010 / Published: 8 July 2010
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Abstract: We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)2Cl2]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.
Keywords: thiosemicarbazone; palladium (II); antibacterial activity; amoxicillin thiosemicarbazone; palladium (II); antibacterial activity; amoxicillin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Asiri, A.M.; Khan, S.A. Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents. Molecules 2010, 15, 4784-4791.

AMA Style

Asiri AM, Khan SA. Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents. Molecules. 2010; 15(7):4784-4791.

Chicago/Turabian Style

Asiri, Abdullah M.; Khan, Salman A. 2010. "Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents." Molecules 15, no. 7: 4784-4791.


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