Molecules 2010, 15(7), 4784-4791; doi:10.3390/molecules15074784
Communication

Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents

Abdullah M. Asiri 1,2  and Salman A. Khan 1,* email
1 Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia 2 The Center of Excellence for Advanced Materials, King Abdul Aziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 13 May 2010; in revised form: 28 May 2010 / Accepted: 9 June 2010 / Published: 8 July 2010
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Abstract: We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)2Cl2]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.
Keywords: thiosemicarbazone; palladium (II); antibacterial activity; amoxicillin

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Cite This Article

MDPI and ACS Style

Asiri, A.M.; Khan, S.A. Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents. Molecules 2010, 15, 4784-4791.

AMA Style

Asiri AM, Khan SA. Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents. Molecules. 2010; 15(7):4784-4791.

Chicago/Turabian Style

Asiri, Abdullah M.; Khan, Salman A. 2010. "Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents." Molecules 15, no. 7: 4784-4791.

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