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Molecules 2010, 15(7), 4737-4749; https://doi.org/10.3390/molecules15074737

Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives

1
Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland
2
Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland
3
Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, 6 Grunwaldzka Str., 60-780 Poznań, Poland
*
Authors to whom correspondence should be addressed.
Received: 1 June 2010 / Revised: 29 June 2010 / Accepted: 1 July 2010 / Published: 6 July 2010
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Abstract

Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. 1H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 mg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC – 100 mg/mL).
Keywords: 3-benzofurancarboxylic acid; antimicrobial activity; antifungal activity; X-ray diffraction 3-benzofurancarboxylic acid; antimicrobial activity; antifungal activity; X-ray diffraction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kossakowski, J.; Krawiecka, M.; Kuran, B.; Stefańska, J.; Wolska, I. Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives. Molecules 2010, 15, 4737-4749.

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