Molecules 2010, 15(7), 4737-4749; doi:10.3390/molecules15074737
Article

Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives

1 Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland 2 Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland 3 Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, 6 Grunwaldzka Str., 60-780 Poznań, Poland
* Authors to whom correspondence should be addressed.
Received: 1 June 2010; in revised form: 29 June 2010 / Accepted: 1 July 2010 / Published: 6 July 2010
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Abstract: Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. 1H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 mg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC – 100 mg/mL).
Keywords: 3-benzofurancarboxylic acid; antimicrobial activity; antifungal activity; X-ray diffraction

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MDPI and ACS Style

Kossakowski, J.; Krawiecka, M.; Kuran, B.; Stefańska, J.; Wolska, I. Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives. Molecules 2010, 15, 4737-4749.

AMA Style

Kossakowski J, Krawiecka M, Kuran B, Stefańska J, Wolska I. Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives. Molecules. 2010; 15(7):4737-4749.

Chicago/Turabian Style

Kossakowski, Jerzy; Krawiecka, Mariola; Kuran, Bożena; Stefańska, Joanna; Wolska, Irena. 2010. "Synthesis and Preliminary Evaluation of the Antimicrobial Activity of Selected 3-Benzofurancarboxylic Acid Derivatives." Molecules 15, no. 7: 4737-4749.

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