Molecules 2010, 15(6), 4439-4449; doi:10.3390/molecules15064439
Article

The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells

1, 2, 1, 1, 2, 1, 2, 3 and 1,* email
Received: 4 May 2010; in revised form: 11 June 2010 / Accepted: 17 June 2010 / Published: 21 June 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fifteen novel glycyrrhetinic acid derivatives containing a nitrogen heterocycle at C-30 and with different A-ring substituents were designed and synthesized. All of these derivatives have improved antiproliferative effects against human HL-60 leukemia cells. Compounds with a cyano-enone functionality on the A-ring exhibit greater growth inhibitory effects, compared to those with a 2-hydroxymethylene-3-keto, an isoxazole, or a 2-cyano-3-keto group. N-(2-cyano-3,11-dioxoolean-1,12-dien-30-yl)-4-piperidyl piperidine (9b) was found to be two-fold more potent than methyl 2-cyano-3,11-dioxooleana-1,12- dien-30-oate(CDODO-Me-11).
Keywords: antiproliferative; glycyrrhetinic acid derivative; leukemia; nitrogen heterocycle
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MDPI and ACS Style

Gao, Y.; Guo, X.; Li, X.; Liu, D.; Song, D.; Xu, Y.; Sun, M.; Jing, Y.; Zhao, L. The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells. Molecules 2010, 15, 4439-4449.

AMA Style

Gao Y, Guo X, Li X, Liu D, Song D, Xu Y, Sun M, Jing Y, Zhao L. The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells. Molecules. 2010; 15(6):4439-4449.

Chicago/Turabian Style

Gao, Yuan; Guo, Xin; Li, Xiaojing; Liu, Dan; Song, Dandan; Xu, Ye; Sun, Ming; Jing, Yongkui; Zhao, Linxiang. 2010. "The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells." Molecules 15, no. 6: 4439-4449.

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