Molecules 2010, 15(6), 4423-4438; doi:10.3390/molecules15064423
Article

Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides

Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden
* Author to whom correspondence should be addressed.
Received: 19 May 2010; in revised form: 11 June 2010 / Accepted: 17 June 2010 / Published: 21 June 2010
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Abstract: Salicylidene acylhydrazides are inhibitors of type III secretion in several Gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-amino-pyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-amino-pyrimidine)-2,2-difluoro-ethanols is described in this paper.
Keywords: scaffold hopping; Reformatsky reaction; salicylidene acylhydrazide; type III secretion

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MDPI and ACS Style

Dahlgren, M.K.; Öberg, C.T.; Wallin, E.A.; Janson, P.G.; Elofsson, M. Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides. Molecules 2010, 15, 4423-4438.

AMA Style

Dahlgren MK, Öberg CT, Wallin EA, Janson PG, Elofsson M. Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides. Molecules. 2010; 15(6):4423-4438.

Chicago/Turabian Style

Dahlgren, Markus K.; Öberg, Christopher T.; Wallin, Erika A.; Janson, Pär G.; Elofsson, Mikael. 2010. "Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides." Molecules 15, no. 6: 4423-4438.

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