Next Article in Journal
The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells
Previous Article in Journal
Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6-Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(6), 4423-4438; doi:10.3390/molecules15064423

Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides

Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Received: 19 May 2010 / Revised: 11 June 2010 / Accepted: 17 June 2010 / Published: 21 June 2010
Download PDF [234 KB, uploaded 18 June 2014]

Abstract

Salicylidene acylhydrazides are inhibitors of type III secretion in several Gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-amino-pyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-amino-pyrimidine)-2,2-difluoro-ethanols is described in this paper.
Keywords: scaffold hopping; Reformatsky reaction; salicylidene acylhydrazide; type III secretion scaffold hopping; Reformatsky reaction; salicylidene acylhydrazide; type III secretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dahlgren, M.K.; Öberg, C.T.; Wallin, E.A.; Janson, P.G.; Elofsson, M. Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides. Molecules 2010, 15, 4423-4438.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top